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ComboSyn Inc combosyn software
Combosyn Software, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/combosyn+software/combosyn+software/pmc12198170-3-8-0
Average 90 stars, based on 1 article reviews
combosyn software - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Papillary thyroid cancer organoids harboring BRAF V600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies.
Article Snippet: The Combination Index (CI) values of the indicated drug combinations were analyzed using the ComboSyn software.

Article Title: MST1 downregulates TAZ tumor suppressor protein in multiple myeloma and is a potential therapeutic target.
Article Snippet: We have previously reported that transcriptional activator with PDZ-binding motif (TAZ) functions as a tumor suppressor in multiple myeloma (MM).. MST1 is a serine-threonine kinase upstream of the Hippo-signaling pathway that functions as a tumor suppressor in many non-hematologic malignancies.. However, its role in hematologic malignancies, including MM is still poorly understood.

Article Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Article Snippet: A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC and its targets, including ornithine decarboxylase (ODC), a master regulator of polyamine metabolism.. Elevated polyamines promote tumorigenesis in part by activating DHPS-mediated hypusination of the translation factor eIF5A, thereby inducing MYC biosynthesis.. Thus, MYC, ODC and eIF5A orchestrate a positive feedback loop that represents an attractive therapeutic target for CRC therapy.

Article Title: Mcl-1 is an important target protein for kaempferol from persimmon leaves in sensitizing ABT-199 to induce apoptosis in hepatoma cancer cells.
Article Snippet: Overexpression of Mcl-1 causes hepatocellular carcinoma resistance to Bcl-2 inhibitors, but there are currently no direct Mcl-1 inhibitors available for clinical application.. Our previous research demonstrated that kaempferol from persimmon leaves (KPL) can sensitize ABT-199 to inhibit liver cancer cell proliferation.. This study further explored the effect of KPL sensitizing ABT-199 on liver cancer cell apoptosis and its potential mechanisms.

Article Title: Synergistic effects of 5-fluorouracil in combination with salinomycin promoted ferroptosis via inhibiting SLC7A11/GPX4 in colorectal cancer
Article Snippet: ComboSyn software was used to study whether dual drug combinations synergistically promote each other and their dosage.

Article Title: Papillary thyroid cancer organoids harboring BRAF V600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies.
Article Snippet: Drug interactions were statistical analyzed with ComboSyn Software (ComboSyn Inc. Paramus, NJ) according to the Chou-Talalay method [51, 52].

Article Title: Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma.
Article Snippet: To evaluate the effects of the drug combination, isobolograms were generated using ComboSyn software (ComboSyn, Inc., Paramus, NJ, USA), and the combination index (CI) < 1.0 was considered a synergistic effect.

Article Title: Effect of proteasome inhibitors on canine lymphoma cell response to CHOP chemotherapy in vitro.
Article Snippet: Combination analysis with combosyn software revealed synergism (CI > 1) at low Fa levels when bortezomib and 4-HC were combined in a Cmax:Cmax ratio, and an antagonism at similar Fa when combined in an IC50:IC50 ratio (Figure 2C).



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